DNA-Directed Assembly of Multivalent Lipid Nanoparticles for Targeted T Cell Gene Delivery
Mary D. Kelly, Timothy Q. Vu, Atiriya Iyer, Yiming Luo, Aiden P. Linderman, Lariana Cline, Crystal Sanchez, Neha P. Kamat
This paper develops a DNA-tethering method to rapidly assemble bispecific lipid nanoparticles for targeted T cell mRNA delivery, showing improved targeting and transfection compared to single-targeted LNPs.
Journal of Controlled Release · Mar 29, 2026Peer-reviewedImmunology