Discovery of P1-P2 depeptidized boronic acid based Plasmodium falciparum SUB1 inhibitor
Armands Kazia, Elina Lidumniece, Chrislaine Withers, Owain Donnelly, David Armand Fidock, Michael Blackman, Aigars Jirgensons
This study designs and tests depeptidized boronic acid inhibitors of PfSUB1, finding improved potency but needing further optimization for membrane permeability.
bioRxiv · Nov 3, 2026 · PreprintPharmacology & Toxicology