Michael J. Blackman

This study designs and tests depeptidized boronic acid inhibitors of PfSUB1, finding improved potency but needing further optimization for membrane permeability.

This study shows that phosphorylation of Plasmodium falciparum MyoA at Ser19 dynamically regulates motor speed and is essential for asexual replication.

This study develops an in vitro system to study SERA6 maturation and validates inhibitors that block malaria parasite egress.

This study shows that Plasmodium falciparum undergoes a rapid metamorphosis after invading erythrocytes, mediated by PV6, which aids parasite survival by altering erythrocyte surface area.

This study shows that PP7 is essential for early ring-stage development in Plasmodium falciparum but not for erythrocyte invasion.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

The paper investigates the roles of CDC50 orthologues in Plasmodium falciparum, showing CDC50B modulates merozoite egress via GC interaction while CDC50C is essential for trophozoite maturation and haemoglobin processing.

This study functionally inactivates the Plasmodium falciparum plasmepsin V gene using CRISPR-Cas9 and DiCre recombination, showing it is essential for parasite viability in asexual blood stages.