Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants
Celine F. Santiago, Inken G. Huttner, Ailbhe O Brien, Melissa A. B. Amerudin, Pauline M. Bennett, Jasmina Cvetkovska, Renee Chand, Mark Holt, Gunjan Trivedi, Louis W. Wang, Xiaoping Yang, Kelly Smith, Mathias Gautel, Diane Fatkin, Yaniv Hinits
This study investigates how truncating variants in the ttn.2 gene affect cardiac and skeletal muscle function in zebrafish, showing location-specific differences in disease severity and phenotypes.
Circulation Research · Jan 7, 2026Peer-reviewedCell Biology