Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
Laura Merino‐Cacho, Orhi Barroso‐Gomila, Mónica Pozo-Rodríguez, Veronica Muratore, Claudia Guinea-Pérez, Álvaro Serrano‐Morrás, Coralia Pérez, Sandra Cano-López, Ainhoa Urcullu, Mikel Azkargorta, Ibón Iloro, Carles Galdeano, Jordi Juárez‐Jiménez, Ugo Mayor, Félix Elortza, , James David Sutherland
The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.
Cell Communication and Signaling · Feb 19, 2025Peer-reviewedCell Biology