Author

James David Sutherland

CIC bioGUNEORCID 0000-0003-3229-793XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Félix ElortzaiD· 3 shared Mikel AzkargortaiD· 3 shared Amaia Zabala‐LetonaiD· 2 shared Arkaitz CarracedoiD· 2 shared Ianire AstobizaiD· 2 shared Ibón IloroiD· 2 shared Natalia Martín-MartíniD· 2 shared Rosa BarrioiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Félix ElortzaORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 2, 2025

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Laura Bozal‐Basterra, María-Camila Salazar, Ana Margarida Ferreira Campos…·Arkaitz Carracedo

This study shows that loss of UFMylation promotes prostate cancer metastasis by reprogramming glucose metabolism towards hexosamine biosynthesis.

DOI 10.1101/2025.06.02.657324

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCell Death and DiseasePeer-reviewedApr 23, 2025

Secreted spermidine synthase reveals a paracrine role for PGC1a-induced growth suppression in prostate cancer

Ariane Schaub-Clerigué, Ivana Heřmanová, Ainara Pintor-Rial…·Verónica Torrano

This study identifies spermidine synthase as a PGC1-regulated secreted protein that mediates paracrine tumor suppression in prostate cancer, highlighting a non-cell autonomous mechanism.

3 citations

humanbulk RNA-seq

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Cell BiologyCell Communication and SignalingPeer-reviewedFeb 19, 2025

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

Laura Merino‐Cacho, Orhi Barroso‐Gomila, Mónica Pozo-Rodríguez…·James David Sutherland

The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.

8 citations

humanproteomics

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