Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms
Chetan Nagaraja, Serena Ortiz, Akash R. Murali, Aiza Sarwar, Theanne N. Griffith
The paper shows that proprioceptor activity drives complement-mediated pruning of intersegmental synapses in the spinal cord, establishing segmental specificity during early development.
bioRxiv · Aug 22, 2025 · PreprintNeuroscience