Serena Ortiz

This study uses an intersectional CRISPR-Cas9 approach to target NaV1.1 in proprioceptors, revealing its essential role in motor coordination and action potential firing.

The paper shows that proprioceptor activity drives complement-mediated pruning of intersegmental synapses in the spinal cord, establishing segmental specificity during early development.

The paper identifies distinct roles for NaV1.1 and NaV1.6 in mammalian proprioception, showing differential effects on motor function and proprioceptive transmission.

This study identifies NaV1.1 as essential for proprioceptive signaling and motor behaviors in mice, showing its role in maintaining reliable proprioceptor firing during sustained muscle stretch.