Identification of Small Molecule Dimethyoxyphenyl Piperazine Inhibitors of Alpha-Synuclein Fibril Growth
Helen Hwang, Dhruva D. Dhavale, Sarah J. Wang, Ajay Guduputi, John M. Beale, Nigel J. Cairns, Paul T. Kotzbauer
The paper identifies two dimethoxyphenyl piperazine analogs that inhibit alpha-synuclein fibril growth in vitro and from Lewy Body Disease brain tissue.
Scientific Reports · Sep 26, 2025Peer-reviewedNeuroscience