Dhruva D. Dhavale

Intrastriatal injection of amplified Lewy body dementia (LBD) fibrils in mice results in accumulation of fibrils with LBD structure and neurodegeneration

The paper shows that injecting amplified Lewy body dementia fibrils into mice leads to fibril accumulation with LBD structure and neurodegeneration.

In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold

The paper reports the high-resolution SSNMR structure of A30P mutant alpha-synuclein fibrils, showing a conserved Greek key fold not including the mutation site, and validates a method for comparing SSNMR spectra of Asyn polymorphs.

Identification of Small Molecule Dimethyoxyphenyl Piperazine Inhibitors of Alpha-Synuclein Fibril Growth

The paper identifies two dimethoxyphenyl piperazine analogs that inhibit alpha-synuclein fibril growth in vitro and from Lewy Body Disease brain tissue.

Alpha-Synuclein Fibril Structures Cluster into Distinct Classes

The paper classifies Alpha-synuclein fibril structures into two main polymorph classes using clustering and finds conserved motifs that could guide drug design.

Seeding competent TDP-43 persists in human patient and mouse muscle

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

This study determines the atomic structure of alpha-synuclein fibrils from Lewy body dementia tissue using a novel amplification method and solid-state NMR.

VCP protects neurons from proteopathic seeding

This study identifies VCP as a suppressor of proteopathic seeding and shows that VCP dysfunction increases seeding of multiple aggregates, contributing to neurodegeneration.

TDP-43 oligomers detected as initial intermediate species during aggregate formation

This study identifies TDP-43 oligomers as early intermediates in aggregation, showing ALS-linked mutations accelerate this process and enhance aggregate propagation.