A common tag nucleotide variant in MMP7 promoter increases risk for hypertension via enhanced interactions with CREB transcription factor
Lakshmi Subramanian, Sakthisree Maghajothi, Mrityunjay Singh, Kousik Kesh, Kalyani Ananthamohan, Saurabh Sharma, Madhu Khullar, Suma M. Victor, Snehasikta Swarnakar, Shailendra Asthana, Ajit S. Mullasari, Nitish R. Mahapatra
This study identifies a SNP in the MMP7 promoter that increases hypertension risk by enhancing CREB binding and MMP7 expression under stress conditions.
bioRxiv · Mar 6, 2019 · PreprintGenetics