Snehasikta Swarnakar

Interleukin-4 suppresses TIMP-2 transcription during endometriosis: Allele-specific regulation of the TIMP-2 -418G/C promoter by SP1

This study identifies an IL-4-SP1-TIMP-2 regulatory axis that contributes to ECM dysregulation in endometriosis and shows the TIMP-2 -418G/C promoter polymorphism affects cytokine-mediated transcription.

A common tag nucleotide variant in MMP7 promoter increases risk for hypertension via enhanced interactions with CREB transcription factor

This study identifies a SNP in the MMP7 promoter that increases hypertension risk by enhancing CREB binding and MMP7 expression under stress conditions.