WISP1 drives a mechanically active immune modulatory and proliferative cardiac myofibroblast state
Sharon Parkins, Sarah Anthony, Teagan K. Goldsworthy, Akanksha Nigam, Neva C. Schehl, Robert M. Jaggers, Daniel A. Kasprovic, Lisa C. Green, Onur Kanisicak, Michael Tranter
This study shows WISP1 drives a unique proliferative and immune-modulatory myofibroblast state in cardiac fibroblasts, acting through a non-canonical P38 MAPK pathway.
bioRxiv · Feb 19, 2026 · PreprintCell Biology