Onur Kanisicak

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

This study shows that activated pulmonary fibroblasts during Aspergillus fumigatus infection enhance lung defense through immunomodulation and tissue remodeling.

This study shows WISP1 drives a unique proliferative and immune-modulatory myofibroblast state in cardiac fibroblasts, acting through a non-canonical P38 MAPK pathway.

This study shows that re-expressing MCM2 in adult cardiomyocytes promotes the secretion of pro-angiogenic cardiosomes, improving cardiac function and reducing fibrosis after myocardial infarction.

This study shows that inhibiting HuR reduces cardiac remodeling after ischemia-reperfusion injury by dampening inflammatory gene expression and immune response, but not initial infarct size.

This study shows that HuR-dependent Wisp1 expression is necessary for TGFβ-induced cardiac myofibroblast activity, as HuR inhibition reduces ECM remodeling and contractile functions.

This study identifies zDHHC3 as a critical regulator of cardiac hypertrophy by enhancing Rac1 S-palmitoylation and RhoGTPase signaling in cardiomyocytes.