Structural basis for the folding of PINK1 by the HSP90-CDC37 chaperone complex
Kei Okatsu, Hayato Yamamoto, Akinori Okamoto, Shinya H. Goto, Yumiko Nishimoto, Yukihiko Sugita, Takeshi Noda, Shuya Fukai
This study presents the cryo-EM structure of the PINK1-HSP90-CDC37 complex, revealing how HSP90-CDC37 stabilizes PINK1 and how mutations may disrupt this process.
bioRxiv · Oct 17, 2025 · PreprintMolecular Biology