Shuya Fukai

This study investigates how the p97/VCP mutation D395G increases redox sensitivity, leading to oxidative inactivation and contributing to neurodegeneration.

This study presents the cryo-EM structure of the PINK1-HSP90-CDC37 complex, revealing how HSP90-CDC37 stabilizes PINK1 and how mutations may disrupt this process.

This study determines the cryo-EM structure of the heterohexameric LGI1-ADAM22 complex and visualizes its dynamics using high-speed atomic force microscopy.

This study shows that Neurexins are essential for cerebellar granule cell survival by organizing autocrine neurotrophin secretion machinery, independent of postsynaptic contact.