Curvature-sensing peptide functions as a membrane interfactant that glues small extracellular vesicles to cell membranes and enhances vesicle cellular uptake
Kenichi Kawano, Kenta Hosokawa, Aoi Taniguchi, Yuuto Oosugi, Akinori Soga, Jun Kawamoto, Yuki Kuzuma, Katsumi Matsuzaki
This study develops a dimeric curvature-sensing peptide that enhances sEV cellular uptake and drug loading, showing fivefold and 20fold increases in uptake and peptide accumulation, respectively.
ACS Applied Bio Materials · Nov 7, 2025Peer-reviewedBiochemistry