Katsumi Matsuzaki

Analytical methodology for unveiling the physical effect of detergents on the function of full-length membrane proteins using a single-molecule tracking system

This paper develops a single-molecule tracking method to assess ligand-binding ability of full-length β2AR without purification, revealing how detergent microenvironments affect protein stability and function.

Curvature-sensing peptide functions as a membrane interfactant that glues small extracellular vesicles to cell membranes and enhances vesicle cellular uptake

This study develops a dimeric curvature-sensing peptide that enhances sEV cellular uptake and drug loading, showing fivefold and 20fold increases in uptake and peptide accumulation, respectively.