Bidirectional modulation of aging-associated cellular phenotypes by mitochondrial genome replacement
Fumiya Teruyama, Toshihiko Taya, Akira Shikuma, Satoaki Matoba, Kentaro Numajiri, Sayako Umetani, Yutong Chen, Amnon Peled, Eithan Galun, Nimer Assy, Aviad Zick, Silvia Noiman, Dayana Michel, Dori Pelled, Taro Inaba, , Satoshi Gojo
This study shows mitochondrial genome replacement can reverse or accelerate aging-related cellular decline in fibroblasts and T cells from mice and humans.
bioRxiv · Jun 30, 2026 · PreprintCell Biology