Aviad Zick

Bidirectional modulation of aging-associated cellular phenotypes by mitochondrial genome replacement

This study shows mitochondrial genome replacement can reverse or accelerate aging-related cellular decline in fibroblasts and T cells from mice and humans.

Improved deconvolution of circulating tumor DNA from ultra-low-pass whole-genome methylation sequencing using CelFiE-ISH

This study improves ctDNA deconvolution in ULP-WGS data using CelFiE-ISH, achieving lower cancer fraction detection limits than CNA benchmarks.

DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival

This paper uses DNA methylation-based deconvolution to analyze glioblastoma cellular composition and identifies astrocyte-to-oligodendrocyte ratios as prognostic markers for patient survival.

Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing

This study demonstrates the ability to detect cell-of-origin and cancer-specific methylation features from cell-free DNA using Oxford Nanopore sequencing.

ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programs

The paper introduces cfChIP-seq to analyze cell-free nucleosomes and shows it can detect disease-related transcriptional changes and patient-specific features in cancer.

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

The paper develops a method to determine the tissue origins of circulating cell-free DNA using a methylation atlas and validates it in healthy and disease states.

Specific detection of cell-free DNA derived from intestinal epithelial cells using methylation patterns

The paper identifies methylation patterns specific to intestinal epithelial cells to detect cell-free DNA in plasma, showing increased levels in advanced CRC compared to IBD and PDAC.