Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages
Akishige Ikegame, Akihiro Kondo, Tatsuya Morinishi, Yusuke Yamaguchi, Yui Okutani, Chinatsu Maegawa, Satoshi Tada
The paper shows that proteinase 3 in M1 macrophages degrades NET-derived CD14, leading to presepsin production, and links NET phagocytosis to P-SEP levels.
Scientific Reports · Dec 19, 2025Peer-reviewedCell Biology