Cell BiologyScientific ReportsPeer-reviewed
Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages
Akishige Ikegame, Akihiro Kondo, Tatsuya Morinishi…·Satoshi Tada
The paper shows that proteinase 3 in M1 macrophages degrades NET-derived CD14, leading to presepsin production, and links NET phagocytosis to P-SEP levels.
DOI 10.1038/s41598-025-32574-x