Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets
Audrey Kishishita, Sabine Cismoski, Tianna Grant, Rucha Deo, Sanjana Prudhvi, Catherine Sue, Abhilash Barpanda, Clinton Yu, Sanjyot Vinayak Shenoy, Sarah Berman, Audrey G. Reeves, Haolong Li, Tianyi Liu, Akul Naik, Deeptarup Biswas, , Arun P. Wiita
This paper expands structural surfaceomics to identify cancer-specific protein conformations across multiple tumor models, revealing potential immunotherapy targets through crosslinking mass spectrometry and structural modeling.
bioRxiv · May 18, 2026 · PreprintCancer Biology