Sexually dimorphic interzonal crosstalk reshapes the adrenal cortex in response to pathophysiological challenges
Nicolò Faedda, Alaa B Abdellatif, Francesco Carbone, May Fayad, Bakhta Fedlaoui, Rita Chamoun, Romane L’Héritier, Ilaria Del Gaudio, Ourida Koual, Isabelle Giscos-Douriez, Stéphanie Baron, Ben Atkinson, Xiaomin Li, Linghui Kong, Yunling Xu, , Maria‐Christina Zennaro
This study shows that environmental factors like diet and dexamethasone induce sex-specific changes in adrenal cortex zones through cell lineage conversion and transcriptional reprogramming.
bioRxiv · Sep 5, 2025 · PreprintPhysiology