GLP-1R agonist NLY01 reduces retinal inflammation, astrocyte reactivity, and retinal ganglion cell death secondary to ocular hypertension.
Jacob K. Sterling, Modupe O. Adetunji, Samyuktha Guttha, Albert Bargoud, Katherine E. Uyhazi, Ahmara G. Ross, Joshua L. Dunaief, Qi N. Cui
This study shows that NLY01 reduces A1 astrocyte formation and retinal ganglion cell death in a glaucoma mouse model by targeting neuroinflammatory pathways.
Cell Reports · Nov 1, 2020Peer-reviewedNeuroscience