Katherine E. Uyhazi

Single-cell spatial transcriptomics of inherited retinal degeneration reveals broad and focal organization of disease responses

The paper uses single-cell spatial transcriptomics to map transcriptional responses to inherited retinal degeneration across the retinal axis, revealing both broad and focal spatial organization of disease-related gene expression.

GLP-1R agonist NLY01 reduces retinal inflammation, astrocyte reactivity, and retinal ganglion cell death secondary to ocular hypertension.

This study shows that NLY01 reduces A1 astrocyte formation and retinal ganglion cell death in a glaucoma mouse model by targeting neuroinflammatory pathways.

Pumilio Proteins Exert Distinct Biological Functions and Multiple Modes of Post-Transcriptional Regulation in Embryonic Stem Cell Pluripotency and Early Embryogenesis

This study identifies distinct roles of Pum1 and Pum2 in ESC pluripotency and embryogenesis, revealing novel post-transcriptional regulatory mechanisms.