Joshua L. Dunaief

This study uses scRNA-seq to analyze retinal cell-type-specific responses to bacterial infection in a mouse model, identifying iron dysregulation and hypoxia as key features.

This study examines temporal and cell-specific changes in iron sequestration and lipid peroxidation in a murine model of neonatal hypoxic-ischemic brain injury, finding acute iron and DHA peroxidation correlate with cell death peaks at 24h post-injury.

This study develops Cy3-PLGA nanoparticles that restore lysosomal pH and function in retinal pigment epithelial and astrocyte cells, showing sustained delivery and retention for at least 28 days.

This study shows that NLY01 reduces A1 astrocyte formation and retinal ganglion cell death in a glaucoma mouse model by targeting neuroinflammatory pathways.