Spatial multi-omics of multiple myeloma uncovers niche-dependent pro-myeloma and immunosuppressive signaling in the bone marrow and extramedullary lesions
Denis J. Ohlstrom, Marina E. Michaud, Mojtaba Bakhtiari, Junia Vieira Dos Santos, William Pilcher, Alden Staub, Sarthak Satpathy, Katherine E. Ferguson, Sowmitri Karthikeya Mantrala, Seunghee Kim‐Schulze, Zhihong Chen, Sagar Lonial, Melissa Lambeth Kemp, Daniel W. Sherbenou, Alessandro Laganà, , Manoj Bhasin
This study uses spatial and single-cell transcriptomics to identify niche-specific signaling programs in multiple myeloma that drive progression and immunosuppression.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology