Author

David L. Jaye

Emory UniversityORCID 0000-0001-7977-6909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ajay K. NookaiD· 2 shared Sagar LonialiD· 2 shared Alden Staub· 1 shared Alessandro LaganàiD· 1 shared Benjamin G. BarwickiD· 1 shared Craig C. HofmeisteriD· 1 shared Daniel AuclairiD· 1 shared Daniel W. SherbenouiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Ajay K. NookaORCID

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2 papers

Recent·Most cited

Spatial multi-omics of multiple myeloma uncovers niche-dependent pro-myeloma and immunosuppressive signaling in the bone marrow and extramedullary lesions

Denis J. Ohlstrom, Marina E. Michaud, Mojtaba Bakhtiari, Junia Vieira Dos Santos, William Pilcher, Alden Staub, Sarthak Satpathy, Katherine E. Ferguson, Sowmitri Karthikeya Mantrala, Seunghee Kim‐Schulze, Zhihong Chen, Sagar Lonial, Melissa Lambeth Kemp, Daniel W. Sherbenou, Alessandro Laganà, , Manoj Bhasin

This study uses spatial and single-cell transcriptomics to identify niche-specific signaling programs in multiple myeloma that drive progression and immunosuppression.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Benjamin G. Barwick, Paola E. Neri, Nizar Jacques Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas Anand Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence Boise

The paper identifies IgL translocations in multiple myeloma as a marker of poor prognosis, often misclassified as standard risk due to co-occurrence with hyperdiploidy.

Nature Communications · Apr 23, 2019Peer-reviewedGenomics