The paper integrates coding and noncoding genome annotations to improve transcriptomic analysis, identifying clinically relevant noncoding RNAs in multiple myeloma.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

Spatial multi-omics of multiple myeloma uncovers niche-dependent pro-myeloma and immunosuppressive signaling in the bone marrow and extramedullary lesions

Denis J. Ohlstrom, Marina E. Michaud, Mojtaba Bakhtiari, Junia Vieira Dos Santos, William Pilcher, Alden Staub, Sarthak Satpathy, Katherine E. Ferguson, Sowmitri Karthikeya Mantrala, Seunghee Kim‐Schulze, Zhihong Chen, Sagar Lonial, Melissa Lambeth Kemp, Daniel W. Sherbenou, Alessandro Laganà, , Manoj Bhasin

This study uses spatial and single-cell transcriptomics to identify niche-specific signaling programs in multiple myeloma that drive progression and immunosuppression.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

William Pilcher, Lijun Yao, Edgar Gonzalez‐Kozlova, Yered H. Pita-Juárez, Dimitra Karagkouni, Chaitanya R. Acharya, Marina E. Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Kazuhito Sato, Julia T. Wang, Sarthak Satpathy, Yuling Ma, Jessica Schulman, , Manoj Bhasin

The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.

Nature Cancer · Jan 9, 2026Peer-reviewedGenomics

Longitudinal multi-omic profiling uncovers immune escape and predictors of response in multiple myeloma

Denis J. Ohlstrom, William Pilcher, Marina E. Michaud, Chaitanya R. Acharya, Sarthak Satpathy, Edgar Gonzalez‐Kozlova, Reyka G. Jayasinghe, Katherine E. Ferguson, Hope Mumme, Shivani Nanda, Yizhe Song, Sowmitri Karthikeya Mantrala, Dimitra Karagkouni, Jessica Schulman, Nick Pabustan, , Manoj Bhasin

This study uses longitudinal multi-omic profiling to identify immune escape mechanisms and predictors of response in multiple myeloma.

bioRxiv · May 27, 2025 · PreprintCancer Biology

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

Delta Ghoshal, Ingrid Petersen, Rachel Ringquist, Liana Kramer, Eshant Bhatia, Thomas Hu, Ariane Richard, Reda Park, Jenna Corbin, Savi Agarwal, Abel Thomas, Sebastián Ramírez, Jacob Tharayil, Emma Downey, Frank Ketchum, , Krishnendu Roy

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass Study

Sheri Skerget, Daniel Peñaherrera, Ajai Chari, Sundar Jagannath, David Samuel DiCapua Siegel, Ravi Vij, Gregory Joshua Orloff, Andrzej J. Jakubowiak, Rubén Niesvizky, Darla Liles, Jesús G. Berdeja, Moshe Yair Levy, Jeffrey Lee Wolf, Saad Z. Usmani, The MMRF CoMMpass Network, , Jonathan J. Keats

The paper identifies genomic subtypes of multiple myeloma using the MMRF CoMMpass study and finds that 25.5% of patients transition to a high-risk expression subtype at progression, which expresses immunotherapy targets.

medRxiv · Aug 2, 2021 · PreprintGenetic & Genomic Medicine

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Benjamin G. Barwick, Paola E. Neri, Nizar Jacques Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas Anand Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence Boise

The paper identifies IgL translocations in multiple myeloma as a marker of poor prognosis, often misclassified as standard risk due to co-occurrence with hyperdiploidy.

Nature Communications · Apr 23, 2019Peer-reviewedGenomics