High-throughput discovery of arginine-depleted peptides enables effective antisense delivery for Duchenne muscular dystrophy
Charlotte E. Farquhar, Nathan W. Dow, Carly K. Schissel, Anirban Bardhan, Alex J. Callahan, Christopher D. Greer, Alec M. Wright, Anindita Mitra, Kristin Ha, Perla G. Castaneda, Emily G. Thompson, Tushare Jinadasa, Ryan A. Oliver, Kathy Ye Morgan, Vincent Guerlavais, Bradley L. Pentelute
This paper develops a high-throughput platform to discover arginine-depleted cell-penetrating peptides for improved antisense delivery in Duchenne muscular dystrophy, showing reduced toxicity and enhanced efficacy.
bioRxiv · Jun 11, 2026 · PreprintBioengineering