Cancer Drug Bortezomib, a Proteasomal Inhibitor, Triggers Cytotoxicity in Microvascular Endothelial Cells via Multi-Organelle Stress
Prajakta Sawant, Aleena Mathew, Johanna Bensalel, Julio Gallego‐Delgado, Pratyusha Mandal
This study shows Bortezomib induces apoptosis in microvascular endothelial cells through ER and mitochondrial stress, distinct from Carfilzomib, and highlights its toxicity mechanisms.
bioRxiv · Mar 25, 2025 · PreprintCell Biology