Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor's brains
Tomoyo Sawada, Amilton de Lima Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord, Laura D’Ignazio, Kynon JM Benjamin, Arthur Sant’Anna Feltrin, Ria Arora, Anna C. Brandtjen, Joel E. Kleinman, Thomas M. Hyde, Daniel R. Weinberger, Apuã C.M. Paquola, Jennifer A. Erwin
The paper uses ventral forebrain organoids from schizophrenia patients and controls to show accelerated maturation of inhibitory neurons and shared gene expression patterns with postmortem brain tissue.
bioRxiv · May 26, 2022 · PreprintNeuroscience