Jennifer A. Erwin

Lifespan analysis of repeat expression reveals age-dependent upregulation of HERV-K in the neurotypical human brain

The paper analyzes repeat expression across the human lifespan in the neurotypical brain, identifying age-dependent upregulation of HERV-K in older adults.

DeepMosaic: Control-independent mosaic single nucleotide variant detection using deep convolutional neural networks

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

Transcriptional and genetic sex differences for schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus

The paper identifies sex differences in schizophrenia across three brain regions using RNA-seq and genotypes, finding sex-specific genes, eQTLs, and transcriptional features.

Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism

This study characterizes TAF1 expression variation in XDP female carriers and human brain ontogeny, identifying age- and region-specific patterns that may explain neostriatum vulnerability in XDP.

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor's brains

The paper uses ventral forebrain organoids from schizophrenia patients and controls to show accelerated maturation of inhibitory neurons and shared gene expression patterns with postmortem brain tissue.

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.

A single cell trajectory of human archetypal pluripotent stem cell differentiation to trophoblast stem cells reveals induction of endogenous BMP5/7 and GATA3 without transitioning through a naive state

This paper shows that primed human pluripotent stem cells can differentiate to trophoblast stem cells without becoming naive, using specific signaling conditions and revealing a transcriptional network involving BMP5/7 and GATA3.

A framework for collaborative computational research

The paper introduces a framework for organizing and reproducibly conducting computational analyses of high-throughput biological data through structured methods and tools.