GSTT1 mediates stemness and FGFR inhibitor sensitivity in pancreatic cancer through regulation of CD133 (PROM1)
Deborah de la Caridad Delgado Herrera, Alejandro Arroyo Roman, Riyan N. Campbell, Emily Lasse-Opsahl, Carrie L McCracken, Lisa Sadzewicz, Luke J. Tallon, Elana J. Fertig, Christina M. Ferrer
This study identifies GSTT1HighCD133High cells as a stem-like subpopulation in pancreatic cancer that is sensitive to FGFR inhibitors, highlighting a therapeutic target.
bioRxiv · Aug 6, 2025 · PreprintCancer Biology