The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

bioRxiv · Sep 10, 2025 · PreprintNeuroscience

GSTT1 mediates stemness and FGFR inhibitor sensitivity in pancreatic cancer through regulation of CD133 (PROM1)

Deborah de la Caridad Delgado Herrera, Alejandro Arroyo Roman, Riyan N. Campbell, Emily Lasse-Opsahl, Carrie L McCracken, Lisa Sadzewicz, Luke J. Tallon, Elana J. Fertig, Christina M. Ferrer

This study identifies GSTT1HighCD133High cells as a stem-like subpopulation in pancreatic cancer that is sensitive to FGFR inhibitors, highlighting a therapeutic target.

bioRxiv · Aug 6, 2025 · PreprintCancer Biology

The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain

Seth A. Ament, Ricky S. Adkins, Robert Carter, Elena Chrysostomou, Carlo Colantuoni, Jonathan Crabtree, Heather H. Creasy, Kylee Degatano, Victor Felix, Peter Gandt, Gwenn A. Garden, Michelle Gwinn Giglio, Brian R. Herb, Farzaneh Khajouei, Elizabeth A. Kiernan, , Owen R. White

The paper describes the Neuroscience Multi-Omic Archive, a repository for single-cell transcriptomic and epigenomic data from mammalian brains, providing tools for data access and analysis.

Nucleic Acids Research · Nov 1, 2022Peer-reviewedGenomics

Cost Effective, Experimentally Robust Differential Expression Analysis for Human/Mammalian, Pathogen, and Dual-Species Transcriptomics

Amol Carl Shetty, John Mattick, Matthew C. Chung, Carrie L McCracken, Anup Mahurkar, Scott G. Filler, Claire M. Fraser, David A. Rasko, Vincent M. Bruno, Julie C. Dunning Hotopp

This study evaluates the impact of read length and pairing on differential expression analysis in host-pathogen interactions, finding 54-bp paired reads most robust and 36-bp single reads suitable for bacterial samples.

Microbial Genomics · Dec 18, 2019Peer-reviewedGenomics