ZATT/ZNF451 promotes release of stalled TOP2 cleavage complexes
Xueyuan Leng, Alessandra Zarantonello, Sampath Amitash Gadi, Ellen S. Kakulidis, Pierre Fey, Andreas Ingham, Ivo Alexander Hendriks, Sidak Minocha, Camilla S. Colding-Christensen, Stella Munkholm Kristensen, Simon Willaume, Natalie Palkova, Christl Gaubitz, Alejandro Garcia Lopez, Poul Martin Bendix, , Julien P. Duxin
This study identifies ZATT/ZNF451 as a key factor in resolving stalled TOP2 cleavage complexes without relying on TDP2, proteolysis, or DSB repair pathways.
bioRxiv · Jul 15, 2026 · PreprintMolecular Biology