Sampath Amitash Gadi

This study identifies ZATT/ZNF451 as a key factor in resolving stalled TOP2 cleavage complexes without relying on TDP2, proteolysis, or DSB repair pathways.

The paper uses proteomics to analyze protein dynamics during replication origin firing in human cells, identifying NCAPH2 as a novel factor required for efficient origin firing.

This study identifies catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis using CRISPR screening and TLS analysis.