Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge
Liana Nunes Barbosa, Alejandro LIanes, Swetha Madesh, Bryanna Nicole Fayne, Kalvis Brangulis, Sarah C. Linn-Peirano, Sreekumari Rajeev
This study evaluates a recombinant Leptospira methyl-accepting chemotaxis protein (MCP) vaccine in C3H/HeJ mice, finding it elicits an immune response but does not prevent disease and may exacerbate clinical signs.
bioRxiv · Apr 17, 2024 · PreprintMicrobiology