MicrobiologyPLoS neglected tropical diseasesPeer-reviewed
Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge
Liana Nunes Barbosa, Alejandro LIanes, Swetha Madesh…·Sreekumari Rajeev
This study evaluates a recombinant Leptospira methyl-accepting chemotaxis protein (MCP) vaccine in C3H/HeJ mice, finding it elicits an immune response but does not prevent disease and may exacerbate clinical signs.
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