Collective Transitions from Orbiting to Matrix Invasion in 3D Multicellular Spheroids
Jiwon Kim, Hee-Won Jeong, Carles Falcó, Alex M. Hruska, W. Duncan Martinson, Alejandro Marzoratti, Mauricio Araiza, Haiqian Yang, Vera C. Fonseca, Stephen A. Adam, Christian Franck, José Antonio Carrillo, Ming Guo, Ian Y. Wong
This study shows epithelial spheroids transition from orbiting to radial matrix invasion via interactions with matrix curvature, with implications for tissue morphogenesis and tumor progression.
Nature Physics · Jan 26, 2026Peer-reviewedBiophysics