Stephen A. Adam

This study shows epithelial spheroids transition from orbiting to radial matrix invasion via interactions with matrix curvature, with implications for tissue morphogenesis and tumor progression.

This study shows that vimentin expression in breast cancer cells changes 3D cluster morphology, enhances migration, and increases cell-matrix interactions.

This study shows vimentin forms liquid droplets that stabilize actin fibers by wetting them, and this behavior is observed in both a mutant and wild-type vimentin.

This paper introduces cTSA-seq, a method to map chromatin near the nuclear lamina from small cell numbers, revealing insights into chromatin organization during early G1 and senescent cells.

The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.

This study shows that both vimentin and keratin intermediate filaments are transported along microtubules via kinesin-1, independent of kinesin light chains, revealing a unified transport mechanism.