Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein
Andrew K. Shum, Sofia Zaichick, Gregory Scott McElroy, Karis B. D’Alessandro, Milad J. Alasady, Michaela M. Novakovic, Wesley Peng, Ekaterina A. Grebenik, Daayun Chung, Margaret E. Flanagan, Roger S. Smith, Alejandro Morales, Laetitia Stumpf, Kaitlyn M. McGrath, Dimitri Krainc, , Gabriela Caraveo
This study shows octopamine reprograms astrocytes to protect neurons from α-synuclein toxicity through metabolic pathways.
Proceedings of the National Academy of Sciences · Apr 17, 2023Peer-reviewedNeuroscience