Author

Roger S. Smith

Northwestern UniversityORCID 0000-0002-6114-8258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Marc L. MendilloiD· 3 shared Alejandro Morales· 1 shared Andrew K. Shum· 1 shared Bin FengiD· 1 shared Brendan P. O’Hara· 1 shared Briana K. DenneheyiD· 1 shared Byoung-Kyu ChoiD· 1 shared Claire M. PhoumyvongiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Marc L. MendilloORCID

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3 papers

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedApr 17, 2023

Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein

Andrew K. Shum, Sofia Zaichick, Gregory Scott McElroy…·Gabriela Caraveo

This study shows octopamine reprograms astrocytes to protect neurons from α-synuclein toxicity through metabolic pathways.

19 citations

mouseproteomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintOct 1, 2022

Beyond BRCA: Discovery of novel causes and consequences of homologous recombination deficiencies

Daniel James McGrail, Yang Li, Roger S. Smith…·Nidhi Sahni

This study identifies RNA binding proteins as novel drivers of homologous recombination deficiency in tumors, expanding the known genetic causes beyond BRCA1/2 mutations.

DOI 10.1101/2022.10.01.510467

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsProceedings of the National Academy of SciencesPeer-reviewedJul 1, 2022

Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response

David R. Amici, Daniel J. Ansel, Kyle A. Metz…·Marc L. Mendillo

The paper constructs a coessential genetic network to map the dynamic cellular stress response across 625 cancer cell lines, identifying key regulators and modules involved in stress resilience.

30 citations

humanwhole-genome sequencing

𝕏 PostBluesky