Author

Karis B. D’Alessandro

Northwestern UniversityORCID 0000-0003-1572-1321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Navdeep S. ChandeliD· 3 shared Colleen R. ReczekiD· 2 shared Jenna L. E. BlumiD· 2 shared Shawn M. DavidsoniD· 2 shared Alec PalmiottiiD· 1 shared Alec R. KossiD· 1 shared Alejandro Morales· 1 shared Andrew K. Shum· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPhysiology

Navdeep S. ChandelORCID

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintOct 2, 2025

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

Zachary L. Sebo, Ram Prosad Chakrabarty, Rogan A. Grant…·Navdeep S. Chandel

This study shows metformin lowers blood glucose by inhibiting intestinal mitochondrial complex I, increasing lactate and GDF15, and promoting glucose uptake.

2 citations

mousehuman

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Cell BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedSep 25, 2025

Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment

Karis B. D’Alessandro, Enrico Zampese, Jenna L. E. Blum…·Navdeep S. Chandel

This study shows that increasing mitochondrial NAD+ regeneration via MitoLbNOX does not rescue dopaminergic neuron dysfunction caused by complex I impairment in Parkinson's disease mice.

1 citation

mouseexperimental assay

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedApr 17, 2023

Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein

Andrew K. Shum, Sofia Zaichick, Gregory Scott McElroy…·Gabriela Caraveo

This study shows octopamine reprograms astrocytes to protect neurons from α-synuclein toxicity through metabolic pathways.

19 citations

mouseproteomics

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