Dynamic fates of dietary antigen-specific T helper cells in a model of early life oral tolerance
Rachael D. FitzPatrick, Aleksandra M. Przydatek, Dominique M. Gatti, Natasha J. Norton, Jenna M. Lane, Brandon E. Moeller, Andrew N. Robinson, Lisa A. Reynolds
This study investigates the fate of CD4+ T cells during early life oral tolerance development in mice, finding that OVA-specific Tregs and Th2 cells emerge, while Th2 cells are suppressed upon systemic challenge.
bioRxiv · Aug 30, 2025 · PreprintImmunology