The Drosophila SPECC1L homolog, Split Discs, co-localizes with non-muscle myosin II and regulates focal adhesion dynamics.
Aidan Teran, Jeehoon Jung, Amy Platenkamp, Alesandra Pardini, Andy Zhao, Sushruta Chandramouli, Allison Jefferis, Derek A. Applewhite
This study identifies Spdi, the Drosophila homolog of SPECC1L, as a non-muscle myosin II binding protein that regulates focal adhesion dynamics, linking its dysfunction to cranial neural crest cell migration defects.
bioRxiv · Apr 6, 2025 · PreprintCell Biology