Ybx1 guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytes
James M. Jordan, Jixuan Qiao, Chenhui Zou, Sandra Steensels, Fahrettin Haczeyni, Alessandra Fraim, Arturro Mendoza, Ype P. de Jong, Baran A. Ersoy
This study shows Ybx1 promotes adipogenic gene expression in steatotic hepatocytes by interacting with C/EBP and cBAF chromatin-remodeling complexes, contributing to lipid accumulation in liver disease.
bioRxiv · Oct 25, 2024 · PreprintDevelopmental Biology