Author

Chenhui Zou

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Ype P. de JongiD· 5 shared Antonis AthanasiadisiD· 4 shared Catherine A. FreijeiD· 4 shared Charles M. RiceiD· 4 shared Corrine QuirkiD· 4 shared Eleftherios MichailidisiD· 4 shared Georgios DangasiD· 4 shared Yichen ZhouiD· 4 shared

Activity by Year

2024-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

Ype P. de JongORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients

Yingpu Yu, Eleftherios Michailidis, Leon Louis Seifert, Mengyin Zhang, Chenhui Zou, Catherine A. Freije, Georgios Dangas, Antonis Athanasiadis, Andreas S. Puschnik, Audrey Hanson, Evelyn Rocha, Yi-Pei Chen, 洪徐鹏, Corrine Quirk, Yichen Zhou, , Ype P. de Jong

This study identifies that genetic accessibility, not superior fitness, determines the selection of anti-HBs antibody escape variants in patients using in vivo screening.

bioRxiv · Oct 8, 2026 · PreprintMicrobiology

The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

Leon Louis Seifert, Georgios Dangas, Hoyin Chu, Yingpu Yu, Kosuke Ogata, Xupeng Hong, Mengyin Zhang, Yichen Zhou, Chenhui Zou, Alireza Ramandi, Corrine Quirk, Evgenia Moschogianni, Catherine A. Freije, Antonis Athanasiadis, Leonardo Gonzales, , Ype P. de Jong

This study shows that HBV BCP mutations enhance viral replication and alter hepatocyte transcription, linking to specific HCC subtypes.

bioRxiv · Sep 23, 2026 · PreprintMolecular Biology

A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

Ansgar F. Stenzel, Antonis Athanasiadis, Georgios Dangas, Paul Park, Anthi Maslarinou, Evgenia Moschogianni, Allan Henrique Depieri Cataneo, Catherine A. Freije, Yichen Zhou, Kenneth C Levenson, Corrine Quirk, Chenhui Zou, William M. Schneider, Adriano Aguzzi, Charles M. Rice, , Eleftherios Michailidis

The paper develops CRISPR-Cas9 delivery methods for primary human hepatocytes to enable efficient gene editing and screening of HBV host factors.

bioRxiv · Aug 18, 2026 · PreprintGenomics

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

Catherine A. Freije, Georgios Dangas, Antonis Athanasiadis, Evgenia Moschogianni, Madeleine K Sanders, Allan Henrique Depieri Cataneo, Chloe K. Boehm, Maria Bousali, Dar-Yin Li, Sooyoung Lee, Guillaume Cornelis, Gary Lo, Leah B. Soriaga, Amalio Telenti, Julia di Iulio, , Eleftherios Michailidis

The paper identifies HBV host factors using CRISPR screens and human liver chimeric mice, finding that EXOC1 is antiviral and ZCCHC14 is proviral.

bioRxiv · Jul 24, 2026 · PreprintMicrobiology

Ybx1 guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytes

James M. Jordan, Jixuan Qiao, Chenhui Zou, Sandra Steensels, Fahrettin Haczeyni, Alessandra Fraim, Arturro Mendoza, Ype P. de Jong, Baran A. Ersoy

This study shows Ybx1 promotes adipogenic gene expression in steatotic hepatocytes by interacting with C/EBP and cBAF chromatin-remodeling complexes, contributing to lipid accumulation in liver disease.

bioRxiv · Oct 25, 2024 · PreprintDevelopmental Biology