Author

James M. Jordan

Duke UniversityORCID 0000-0002-7620-462XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Organism:C. elegans· 3 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

L. Ryan BaughiD· 3 shared Amy K. WebsteriD· 2 shared Baran A. ErsoyiD· 2 shared Fahrettin HaczeyniiD· 2 shared Jixuan QiaoiD· 2 shared Jonathan D. HibshmaniD· 2 shared Rebecca E. W. KaplaniD· 2 shared Ryan Guzman· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenetics

L. Ryan BaughORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

GeneticsbioRxivPreprintFeb 28, 2025

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegans

Ivan B Falsztyn, Jingxian Chen, Rojin Chitrakar…·L. Ryan Baugh

This paper identifies daf-18/PTEN and lin-35/Rb as tumor suppressors that counteract early life starvation-induced developmental abnormalities in C. elegans by modulating Hedgehog signaling and innate immunity.

DOI 10.1101/2025.02.28.640733

C. elegansDNA methylation

Developmental BiologybioRxivPreprintOct 25, 2024

Ybx1 guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytes

James M. Jordan, Jixuan Qiao, Chenhui Zou…·Baran A. Ersoy

This study shows Ybx1 promotes adipogenic gene expression in steatotic hepatocytes by interacting with C/EBP and cBAF chromatin-remodeling complexes, contributing to lipid accumulation in liver disease.

DOI 10.1101/2024.10.25.620017

mousehuman

Molecular BiologybioRxivPreprintMay 4, 2023

Submitochondrial Protein Translocation in Thermogenic Regulation

Fahrettin Haczeyni, James M. Jordan, Benjamin D. Stein…·Baran A. Ersoy

The paper identifies stress-induced submitochondrial protein translocation as a mechanism regulating thermogenesis and obesity by mobilizing proteins from the mitochondrial inner membrane into the matrix.

DOI 10.1101/2023.05.04.539294

humanproteomics

GeneticsG3 Genes Genomes GeneticsPeer-reviewedAug 23, 2019

Population selection and sequencing of C. elegans wild isolates identifies a region on chromosome III affecting starvation resistance

Amy K. Webster, Anthony Hung, Brad T. Moore…·L. Ryan Baugh

23 citations

C. eleganswhole-genome sequencing

Developmental BiologybioRxivPreprintJun 8, 2018

Intergenerational effects of dietary restriction on insulin/IGF signaling and reproductive development

James M. Jordan, Jonathan D. Hibshman, Rebecca E. W. Kaplan…·L. Ryan Baugh

This study investigates how maternal dietary restriction affects reproductive development in C. elegans by modulating insulin/IGF signaling, reducing starvation-induced abnormalities in progeny.

DOI 10.1101/342956

C. elegansstatistical model